ISG15 COUNTERACTS LISTERIA MONOCYTOGENES INFECTION

ISG15 is an interferon-stimulated, linear di-ubiquitin-like protein, with anti-viral activity.The role of ISG15 during bacterial infection remains elusive.We show that ISG15 expression in nonphagocytic cells is dramatically induced upon hancheng fashion Listeria infection.Surprisingly this induction can be type I interferon independent and depends